On Wednesday October 5th, the Nobel Prize in Chemistry was awarded to three scientists for their development of click chemistry. Together, Dr. Sharpless of Scripps Research, Dr. Meldal of the University of Copenhagen, and Dr. Bertozzi of Stanford University utilized imaginative processes to create and improve upon this branch of chemistry.
This innovative technology will allow scientists to form complex molecules as well as study their cell’s functions. In applying this tech, scientists may combine molecular pieces more effectively, thus creating an efficient way of producing pharmaceuticals essential for disease research. In addition to its help in bioengineering new medicines, this multifaceted innovation will also improve internal cell research. Chemists may now tag molecules within an organism and bioimage them.
When attempting to create such a technology, chemists were at a loss due to the difficulty of forming carbon bonds in a lab. If one was lucky enough to cause a bond between carbon atoms, it would set off numerous side reactions and lead to a loss of material. Thus, Dr. Sharpless proposed that chemists use molecules with an existing carbon frame and connect them with either oxygen or nitrogen. This process would cause far less wasted material and would later be labeled click chemistry by Dr. Sharpless.
During Dr. Sharpless’ research, Dr. Meldal simultaneously uncovered two molecules that were easily bonded by copper ions. In doing so, Dr. Meldal legitimized Dr. Sharpless’s findings and provided a base for click chemistry.
While Dr. Sharpless and Dr. Meldal published and spread their findings, Dr. Bertozzi continued to search for a way to attach a handle and fluorescent tag onto complex carbohydrates known as glycans. Since copper was toxic to living organisms, Dr. Bertozzi was forced to discover another way of using click chemistry. Consequently, Dr. Bertozzi realized a process in which she could make one of the molecules into a ring shape to create enough energy for the reaction without the use of copper.
Though the exploration of Click Chemistry has only just begun, these three Nobel prize winners have opened up a new door that will prove revolutionary to mankind.
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